Background: In middle-income countries, costs limit widespred use of left ventricular assist device (LVAD) as a strategy for end-stage heart failure.We aim to describe the experience of a LVAD program in a middle-income country in a hub-and-spoke model.Methods: Patients fulfilling strict inclusion collirio drop set and exclusion criteria were refer
At an announced tender of a contracting party, in the processes of public procurement of goods or services, a method of decision-making follows after interested bidders submit bids.Such method of choice is characteristic for all business systems with majority share of state capital.Methods of decision-making come down to selecting the best bids, be
The discretization of computational domain is a crucial step in Computational Fluid Dynamics (CFD) because it influences not only the numerical stability of the analysed model but also the agreement of obtained results and real data.Modelling flow in packed beds of granular materials is a very challenging task in terms of discretization due to the
To be effective, RNA vaccines require both in situ translation and the induction of whip carbon magnum an immune response to recruit cells to the site of immunization.These factors can pull in opposite directions with the inflammation reducing expression of the vaccine antigen.We investigated how formulation affects the acute systemic cytokine resp